Efficacy and Safety of Brazilian Green Propolis in Biochemically Recurrent Prostate Cancer after Radical Prostatectomy: A Single-Arm Phase II Study
نویسندگان
چکیده
Background: Radiation or hormonal therapy is considered for prostate cancer patients with biochemical recurrence (BCR) after radical prostatectomy (RP). However, these therapies have their own complications. To delay the start of therapies, we investigated efficacy and safety Brazilian green propolis treatment BCR RP. Materials Methods: This single-center, single-arm open trial included 22 who experienced RP between 2016 2019. The received nine softgels (containing 40 mg per capsule) daily 6 months. primary outcome was prostate-specific antigen (PSA) response rate. secondary outcomes progression-free time, PSA slope (1/PSA doubling time) rate, quality life, profile. Results: rate 0%. mean slopes before baseline were 0.12 month−1 0.08 month−1, respectively. Fifteen (68%) showed a decreased treatment. There no negative effects on life serious adverse events leading to discontinuation. Conclusion: significant anticancer in propolis. administration. Further, may be safely consumed by patients.
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ژورنال
عنوان ژورنال: International journal of translational medicine
سال: 2022
ISSN: ['2673-8937']
DOI: https://doi.org/10.3390/ijtm2040047